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Vilanova I
a commonly used drug
showing dose proportional pharmacokinetics
Chemical Name: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine
AHU-377 hemicalcium salt - CAS# 1369773-39-6 0165 Vilanova IAHU 377 hemicalcium salt, CAS No. 1369773 39 6, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
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